Extracellular matrix gene sequence variant analyses and Achilles tendinopathy

The primary aim of this thesis was to identify additional genetic elements predisposing individuals to risk of AT using a candidate gene, case-control genetic association approach, and to propose the biological mechanisms underlying this genetic risk. Candidate genes (COMP, THBS2, COL27A1, TNC, COL3A1, COL5A2 and COL5A3) were selected based on their chromosomal location and/or the biological function of their encoded proteins within the extracellular matrix (ECM) of the tendon.

Grantor dc:publisher.institution

Department of Human Biology

Year dc:date.issued

2013

Author dc:creator

• Saunders, Colleen Jayne

Advisors dc:contributor.advisor

• September, Alison
• Schwellnus, Martin
• Collins, Malcolm

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3199

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3199