Genetic risk factors for anterior cruciate ligament ruptures

The primary aim of this thesis was to identify candidate genes that may be associated with ACL ruptures, and then use a genetic association approach following a case-control study design to identify specific sequence variants (single nucleotide polymorphisms, SNPs) within these candidate genes which may predispose individuals to ACL ruptures. Candidate genes (COL1A1, COL5A1 and COL12A1) were selected based on the biological function of their encoded proteins (type I, type V and type XII collagen respectively) within the basic structural and functional unit of ligaments, namely the collagen microfibril.

Grantor dc:publisher.institution

Department of Human Biology

Year dc:date.issued

2009

Author dc:creator

• Posthumus, Michael

Advisors dc:contributor.advisor

• Collins, Malcolm
• Schwellnus, Martin

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3195

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3195