{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/31950"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/31950","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"A study comparing the effects of vincristine with those of ionizing radiation on the root meristem of Vicia faba","abstract":"Vincristine and vinblastine, two closely related alkaloids are extracted from the Madagaskar Periwinkle, Vinca rosea Linn. They have been shown to be effective oncolytic agents and cause arrest of mitosis at the metaphase stage, similar to that of colchicine andcolcimid. Clinically, vincristine has been found to produce a complete remission in patients with acute leukaemia. Tumour regression in patients with Hodgkin's disease, lymphosarcoma and certain childhood solid tumours have also been reported.","abstract_html":"Vincristine and vinblastine, two closely related alkaloids are extracted from the Madagaskar Periwinkle, Vinca rosea Linn. They have been shown to be effective oncolytic agents and cause arrest of mitosis at the metaphase stage, similar to that of colchicine andcolcimid. Clinically, vincristine has been found to produce a complete remission in patients with acute leukaemia. Tumour regression in patients with Hodgkin's disease, lymphosarcoma and certain childhood solid tumours have also been reported.","abstract_has_math":false,"creators":["Haddad, Dawne Merle"],"institution":"Department of Human Biology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1972,"date_issued":"1972","date_published":"1972","updated_at":"2026-07-22T22:23:05Z","subjects":["Meristem","Radiation effects"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/11427/31950","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Haddad, Dawne Merle"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2020-05-20T22:00:02Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-05-20T22:00:02Z"]},{"key":"dc:date.issued","label":"Date","values":["1972"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Human Biology"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Meristem","Radiation effects"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/11427/31950"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Vincristine and vinblastine, two closely related alkaloids are extracted from the Madagaskar Periwinkle, Vinca rosea Linn. They have been shown to be effective oncolytic agents and cause arrest of mitosis at the metaphase stage, similar to that of colchicine andcolcimid. Clinically, vincristine has been found to produce a complete remission in patients with acute leukaemia. Tumour regression in patients with Hodgkin's disease, lymphosarcoma and certain childhood solid tumours have also been reported."]},{"key":"dc:title","label":"Title","values":["A study comparing the effects of vincristine with those of ionizing radiation on the root meristem of Vicia faba"]}]}],"canonical_facts":{"dc:creator":["Haddad, Dawne Merle"],"dc:date.accessioned":["2020-05-20T22:00:02Z"],"dc:date.available":["2020-05-20T22:00:02Z"],"dc:date.issued":["1972"],"dc:description.abstract":["Vincristine and vinblastine, two closely related alkaloids are extracted from the Madagaskar Periwinkle, Vinca rosea Linn. They have been shown to be effective oncolytic agents and cause arrest of mitosis at the metaphase stage, similar to that of colchicine andcolcimid. Clinically, vincristine has been found to produce a complete remission in patients with acute leukaemia. Tumour regression in patients with Hodgkin's disease, lymphosarcoma and certain childhood solid tumours have also been reported."],"dc:identifier.uri":["https://hdl.handle.net/11427/31950"],"dc:publisher.department":["Department of Human Biology"],"dc:subject":["Meristem","Radiation effects"],"dc:title":["A study comparing the effects of vincristine with those of ionizing radiation on the root meristem of Vicia faba"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"]},"updated_at":"2026-07-22T22:23:05Z"}