Mechanisms of activation of glycogenolysis during development of malignant hyperthermia in swine

The syndrome of Malignant Hyperpyrexia in man follows administration of certain general anaesthetic agents, and, although rare, is fatal in 70% of cases (EDITORIAL, 1968). Following exposure to the anaesthetic, there is, in most instances of susceptible individuals, a rapid rise in body temperature, usually within a period of 10 minutes, often accompanied by muscular rigidity of the limbs~ Sometimes hyperthermia has.been delayed for hours and muscular rigidity not pronounced. The temperature reached maybe 43°C (115°F) or even somewhat above this. Halothane, CF3CHBrCl, a ha../o/~nated hydrocarbon, is thought to be responsible for most cases(WILSON, NICHOLS, DENT and ALLEN, 1966). Succinyl choline lfH2COOCH2CH2*(cH3 )~ 201_~H2COOCH2CH2~(cH3 )3 a skeletal muscle relaxant employed during anaesthesia, has also been implicated (BRITT and KALOW, 1970; HARRISON, 1971).

Grantor

Department of Anaesthesia and Perioperative Medicine

Year dc:date.issued

1971

Author dc:creator

• Conradie, Paulina Jacoba

Advisor dc:contributor.advisor

• Berman, M

• Glycolysis
• anaesthetic
• malignant hyperpyrexia
• anaesthesia

Handle dc:identifier.uri

https://hdl.handle.net/11427/31878

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/31878