The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring

This study investigates imprinting of the murine fetal immune system by maternal infection with the helminth Nippostrongylus brasiliensis (Nb) prior to pregnancy and its effect on control of the Salmonella enterica serovar typhimurium (STm) in offspring. We show that maternal Nb infection in BALB/c mice results in the transfer of Nb antigen (NES)-specific IgG1 in utero and through breastmilk, changes in lymphocyte populations and early germinal center formation in naive offspring. Maternal Nb infection does not interfere with control of STm in offspring in BALB/c mice, but may interfere with control of STm in C57BL/6 mice.

Grantor dc:publisher.institution

Department of Clinical Laboratory Sciences

Year dc:date.issued

2013

Author dc:creator

• Mrdjen, Dunja

Advisor dc:contributor.advisor

• Horsnell, William

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3175

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3175