The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene

Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated with transcriptional activity and plays a critical role in differential gene expression.

Grantor dc:publisher.institution

Division of Medical Biochemistry

Year dc:date.issued

2002

Author dc:creator

• Ndlovu, Matladi N

Advisor dc:contributor.advisor

• Parker, M Iqbal

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3144

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3144