Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa

Oesophageal squamous cell carcinoma (OSCC) is a complex disease, determined by the interaction of genetic factors with environmental risk factors. In South Africa, OSCC is a major malignancy occurring with high incidence in the Black and Mixed Ancestry populations. Previous studies by our research group have reported that genetic polymorphism of xenobiotic metabolizing enzymes influence greatly the detoxification of tobacco-related carcinogens in vivo, and may therefore have an important role in determining susceptibility to oesophageal cancer.

Grantor dc:publisher.institution

Division of Medical Biochemistry

Year dc:date.issued

2013

Author dc:creator

• Matejcic, Marco

Advisors dc:contributor.advisor

• Parker, M Iqbal
• Mathew, Chris

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3139

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3139