Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts

Stromal cells and the extracellular matrix (ECM) components provide the microenvironment that is pivotal for cell growth, motility, attachment and differentiation. Fibroblasts are some of the cells responsible for the synthesis of most of the extracellular matrix proteins. Type I collagen is the most abundant extracellular matrix protein in the human body and is found in tissues requiring high tensile strength. In this study we investigated the effect of a pre-formed fibroblast-derived extracellular matrix on the expression of type I collagen and associated matrix metalloproteinases in fibroblasts.

Grantor dc:publisher.institution

Division of Medical Biochemistry

Year dc:date.issued

2009

Author dc:creator

• Dzobo, Kevin

Advisor dc:contributor.advisor

• Parker, Iqbal

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3125

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3125