Gene mutations and expression in breast cancer

Breast cancer is the most common cause of death amongst women, with the incidence of the disease varying between countries. Like all other cancers, breast cancer is a multigenic disorder with mutations in oncogenes and tumour suppressor genes playing an important role in cellular transformation and ultimately in tumour formation. In this study, 40 breast cancer patients from the Western Cape province in South Africa and 4 breast cancer cell lines were screened for mutations in the human Ha-ras oncogene and the p53 tumour suppressor gene.

Grantor dc:publisher.institution

Division of Medical Biochemistry

Year dc:date.issued

2000

Author dc:creator

• Donninger, Howard

Advisor dc:contributor.advisor

• Parker, M Iqbal

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3124

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3124