Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies

Lymphocyte-specific reconstitution of IL-4Ra was recently established by intercrossing lymphocyte-specific human IL-R4a transgenic mice with mIL-4Ra-deficient mice. Human IL-4Ra may bind to mouse yc resulting in a chimeric receptor specific for human IL-4 but not mouse IL-4. This provides us with and inducible IL-4 system. The aim of this study was to investigate in vitro and in vivo characteristics of our novel hlL-4Ra Tg/mIL-4Ra+/- mouse model.

Grantor dc:publisher.institution

Division of Immunology

Year dc:date.issued

2006

Author dc:creator

• Myburgh, Elmarie

Advisor dc:contributor.advisor

• Brombacher, Frank

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3114

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3114