A study to investigate the role of P27 and Cyclin E immunoexpression as a prognostic factor in early breast carcinoma

Cyclin E and p27 expression is easy to assess in human tissues by standard immunohistochemical techniques. Immunohistochemistry is cost effective, relatively easy to perform and will play more of a role in the future management of cancer. To investigate the role of p27 and cyclin E immunoexpression as a prognostic factor in early breast carcinoma. Cyclin E and p27 immunohistochemistry was performed on sixty six cases of breast carcinoma submtted over a five year period to the Division of Anatomical Pathology, Groote Schuur hospital; Whittaker and Associates; and PathCare. All tumours included in this study were less than 5cm in diameter (pT1 and pT2 stage) and all the patients had wide local excisions peformed. Follow up information was obtained from patient folders in the Department of Radiation Oncology.

Grantor dc:publisher.institution

Division of Anatomical Pathology

Year dc:date.issued

2006

Author dc:creator

• Pillay, Komala

Advisor dc:contributor.advisor

• Govender, Dhiren

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3085

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3085