Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection

In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses and the production of interleukin (IL)-4 and IL-13, which share a common receptor subunit, the IL-4 receptor alpha chain (IL-4α ). While IL-4 is the main inducer of Th2 responses, paradoxically it has been shown that exogenously administered IL-4 can promote dendritic cell IL-12 production and enhance Th1 development if given early during infection.

Grantor dc:publisher.institution

Institute of Infectious Disease and Molecular Medicine

Year dc:date.issued

2013

Author dc:creator

• Hurdayal, Ramona

Advisors dc:contributor.advisor

• Brombacher, Frank
• Revaz-Breton, Melanie

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3059

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3059