Mitigation of the inflammatory response to bioprosthetic heart valve tissue through antigen-directed masking
This research was firstly directed to characterise the immune response to bioprosthetic heart valves in patients as well as in animal models. The study further demonstrated that the glutaraldehyde concentration applied to commercial heart valves is insufficient to mask the antigenicity of the tissue, therefore an method of masking antigens to mitigate the inflammatory response is needed.
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