{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/2777"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/2777","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Mitigation of the inflammatory response to bioprosthetic heart valve tissue through antigen-directed masking","abstract":"This research was firstly directed to characterise the immune response to bioprosthetic heart valves in patients as well as in animal models. The study further demonstrated that the glutaraldehyde concentration applied to commercial heart valves is insufficient to mask the antigenicity of the tissue, therefore an method of masking antigens to mitigate the inflammatory response is needed.","abstract_html":"This research was firstly directed to characterise the immune response to bioprosthetic heart valves in patients as well as in animal models. The study further demonstrated that the glutaraldehyde concentration applied to commercial heart valves is insufficient to mask the antigenicity of the tissue, therefore an method of masking antigens to mitigate the inflammatory response is needed.","abstract_has_math":false,"creators":["Du Plessis, Engela Helena"],"institution":"Division of Cardiology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Human, Paul"],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009","date_published":"2009","updated_at":"2026-07-22T22:22:47Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/2777","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Human, Paul"]},{"key":"dc:creator","label":"Author","values":["Du Plessis, Engela Helena"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-28T08:25:08Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-28T08:25:08Z"]},{"key":"dc:date.issued","label":"Date","values":["2009"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Cardiology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/2777"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references (leaves 143-165)."]},{"key":"dc:description.abstract","label":"Abstract","values":["This research was firstly directed to characterise the immune response to bioprosthetic heart valves in patients as well as in animal models. The study further demonstrated that the glutaraldehyde concentration applied to commercial heart valves is insufficient to mask the antigenicity of the tissue, therefore an method of masking antigens to mitigate the inflammatory response is needed."]},{"key":"dc:title","label":"Title","values":["Mitigation of the inflammatory response to bioprosthetic heart valve tissue through antigen-directed masking"]}]}],"canonical_facts":{"dc:contributor.advisor":["Human, Paul"],"dc:creator":["Du Plessis, Engela Helena"],"dc:date.accessioned":["2014-07-28T08:25:08Z"],"dc:date.available":["2014-07-28T08:25:08Z"],"dc:date.issued":["2009"],"dc:description":["Includes bibliographical references (leaves 143-165)."],"dc:description.abstract":["This research was firstly directed to characterise the immune response to bioprosthetic heart valves in patients as well as in animal models. 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