The association of the AVPR2 gene with serum sodium and water imbalances during an Ironman Triathlon

It is well documented that participation in ultra-endurance events such as the Ironman Triathlon, can be associated with the development of post-race water and sodium imbalances in athletes. Variants within genes that encode for proteins that regulate thirst have been shown to be associated with weight changes during participation in an Ironman Triathlon. Recent evidence of mutations within the arginine vasopressin 2 receptor (AVPR2) gene, which encodes a constitutively active receptor in the collecting tubules of the kidney, resulted in increased water reabsorption and hyponatraemia in two unrelated male infants. This suggests that serum imbalances and hydration status in individuals participating in an endurance event may also be, in part, controlled by variants withink the AVPR2 gene. The aim of this study was to investigate whether polymorphisms within the AVPR2 gene are associated with exercise-associated serum sodium and/or water imbalances in triathletes who particpated in the 2006 South African Ironman Triathlon.

Grantor dc:publisher.institution

MRC/UCT RU for Exercise and Sport Medicine

Year dc:date.issued

2007

Author dc:creator

• Ah Kun, Maresa

Advisor dc:contributor.advisor

• Collins, Malcolm

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/2774

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/2774