Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide

Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to elucidate four aspects of the physiology and pathophysiology of this candidate hormone. Firstly, factors affecting the release of human PP (hPP) were assessed in healthy subjects; secondly polyacrylamide gel electrophoresis was used to investigate molecular heterogeneity of the peptide; thirdly, the organ uptake and half-life time of endogenous PP was measured in pigs; and finally, basal and stimulated serum hPP concentrations were assayed in patients with acute pancreatitis, chronic pancreatitis and maturity-onset diabetes mellitus.

Grantor dc:publisher.institution

Division of Endocrinology and Diabetology

Year dc:date.issued

1982

Author dc:creator

• Sive, Alan Avrom

Advisor dc:contributor.advisor

• Vinik, A I

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/26525

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/26525