Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias

Ventricular arrhythmias are difficult to study in man. The current experimental models are arrhythmias induced by electrical stimulation, coronary artery ligation or by subsequent reperfusion. An electrophysiological model will be useful for exploring the cellular mechanism of arrhythmias and for studying the mechanism of action of new anti-arrhythmic drugs. This project seeks to establish automaticity as a model for studying ventricular arrhythmias. Objectives 1. To review the literature on the mechanism of ventricular arrhythmias. 2. To explore ventricular automaticity induced by "reperfusion" after O₂ and substrate deprivation. 3 . To explore beta-adrenoceptor mediated ventricular automaticity. 4 . To evaluate possible new anti-arrhythmic drugs, carminomycin and ketanserin.

Grantor dc:publisher.institution

MRC/UCT Cape Heart Centre

Year dc:date.issued

1984

Author dc:creator

• Saman, Selva

Advisor dc:contributor.advisor

• Opie, Lionel H

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/25564

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/25564