{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/22760"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/22760","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum","abstract":"The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synthetic haemozoin, β-haematin, to parasite survival. However, haemozoin inhibition with a dose related increase in \"free\" haem correlated to decreased survival has not been demonstrated in the parasite. This project investigated the role of haem in the mechanism of action of several clinically relevant and novel antimalarials in the malaria parasite, Plasmodium falciparum.","abstract_html":"The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synthetic haemozoin, β-haematin, to parasite survival. However, haemozoin inhibition with a dose related increase in "free" haem correlated to decreased survival has not been demonstrated in the parasite. This project investigated the role of haem in the mechanism of action of several clinically relevant and novel antimalarials in the malaria parasite, Plasmodium falciparum.","abstract_has_math":false,"creators":["Combrinck, Jill Michelle"],"institution":"Division of Clinical Pharmacology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Egan, Timothy J","Smith, Peter"],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-07-22T22:23:47Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/22760","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Egan, Timothy J","Smith, Peter"]},{"key":"dc:creator","label":"Author","values":["Combrinck, Jill Michelle"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-01-17T12:23:31Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-01-17T12:23:31Z"]},{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Clinical Pharmacology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/22760"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synthetic haemozoin, β-haematin, to parasite survival. However, haemozoin inhibition with a dose related increase in \"free\" haem correlated to decreased survival has not been demonstrated in the parasite. This project investigated the role of haem in the mechanism of action of several clinically relevant and novel antimalarials in the malaria parasite, Plasmodium falciparum."]},{"key":"dc:title","label":"Title","values":["The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum"]}]}],"canonical_facts":{"dc:contributor.advisor":["Egan, Timothy J","Smith, Peter"],"dc:creator":["Combrinck, Jill Michelle"],"dc:date.accessioned":["2017-01-17T12:23:31Z"],"dc:date.available":["2017-01-17T12:23:31Z"],"dc:date.issued":["2016"],"dc:description.abstract":["The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synthetic haemozoin, β-haematin, to parasite survival. However, haemozoin inhibition with a dose related increase in \"free\" haem correlated to decreased survival has not been demonstrated in the parasite. This project investigated the role of haem in the mechanism of action of several clinically relevant and novel antimalarials in the malaria parasite, Plasmodium falciparum."],"dc:identifier.uri":["http://hdl.handle.net/11427/22760"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Clinical Pharmacology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:47Z"}