{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/22140"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/22140","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"A study of activated ketal reduction with borane dimenthyl sulphide","abstract":"Carbonyl reduction to secondary alcohols is a fundamentally important reaction in organic chemistry and many reagents have been developed for achieving this transformation efficiently, with regard to both the optical and material yield. An alternative approach, popularized in recent times, is the dissociative reduction of ketals to afford ethers as protected secondary derivatives and a number of approaches accomplishing a high degree of stereoselectivity have been developed. This thesis describes a study of a novel reagent combination, namely borane dimethyl sulphide and trimethylsilyl trifluoromrthanesulphonate (TMSOTf) for reductive ketal cleavage.","abstract_html":"Carbonyl reduction to secondary alcohols is a fundamentally important reaction in organic chemistry and many reagents have been developed for achieving this transformation efficiently, with regard to both the optical and material yield. An alternative approach, popularized in recent times, is the dissociative reduction of ketals to afford ethers as protected secondary derivatives and a number of approaches accomplishing a high degree of stereoselectivity have been developed. This thesis describes a study of a novel reagent combination, namely borane dimethyl sulphide and trimethylsilyl trifluoromrthanesulphonate (TMSOTf) for reductive ketal cleavage.","abstract_has_math":false,"creators":["Bartels, Birgit"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Hunter, Roger"],"committee_chairs":[],"committee_members":[],"year":1992,"date_issued":"1992","date_published":"1992","updated_at":"2026-07-22T22:22:54Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/22140","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Hunter, Roger"]},{"key":"dc:creator","label":"Author","values":["Bartels, Birgit"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-10-14T06:27:31Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-10-14T06:27:31Z"]},{"key":"dc:date.issued","label":"Date","values":["1992"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/22140"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Carbonyl reduction to secondary alcohols is a fundamentally important reaction in organic chemistry and many reagents have been developed for achieving this transformation efficiently, with regard to both the optical and material yield. An alternative approach, popularized in recent times, is the dissociative reduction of ketals to afford ethers as protected secondary derivatives and a number of approaches accomplishing a high degree of stereoselectivity have been developed. This thesis describes a study of a novel reagent combination, namely borane dimethyl sulphide and trimethylsilyl trifluoromrthanesulphonate (TMSOTf) for reductive ketal cleavage."]},{"key":"dc:title","label":"Title","values":["A study of activated ketal reduction with borane dimenthyl sulphide"]}]}],"canonical_facts":{"dc:contributor.advisor":["Hunter, Roger"],"dc:creator":["Bartels, Birgit"],"dc:date.accessioned":["2016-10-14T06:27:31Z"],"dc:date.available":["2016-10-14T06:27:31Z"],"dc:date.issued":["1992"],"dc:description.abstract":["Carbonyl reduction to secondary alcohols is a fundamentally important reaction in organic chemistry and many reagents have been developed for achieving this transformation efficiently, with regard to both the optical and material yield. An alternative approach, popularized in recent times, is the dissociative reduction of ketals to afford ethers as protected secondary derivatives and a number of approaches accomplishing a high degree of stereoselectivity have been developed. This thesis describes a study of a novel reagent combination, namely borane dimethyl sulphide and trimethylsilyl trifluoromrthanesulphonate (TMSOTf) for reductive ketal cleavage."],"dc:identifier.uri":["http://hdl.handle.net/11427/22140"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["A study of activated ketal reduction with borane dimenthyl sulphide"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:22:54Z"}