Intra- and intermolecular reactivity of organic diacyl systems

The mechanism or a thermal amino group transfer-fragmentation reaction yielding carboxyamides from mixed phosphoric-carboxylic anhydrides (RO(R¹R²N)P(O)OC(O)R³; R = R¹ = alkyl; R² = H, alkyl, aryl; R³ = alkyl, aryl) was elucidated from structure reactivity studies using a model system, R = R¹ = R² = Me, R³ = Ph. Kinetic data was obtained using ¹H nmr spectroscopy; MNDO molecular orbital and molecular mechanics calculations, and the crystal structure or N-methyl-2-benzoyloxy-2-oxo-1, 3, 2-oxazaphosphorinane (Pna2₁; a = 22.229(6)Å, b = 7.597(2)Å, c = 7.210(2)Å; v = 1217.6(6)ų. Final R = 3. 08% for 1037 reflections with I (rel )> 2αI (rel) and 15 7 parameters) were userul in providing additional in formation about the reaction mechanism .

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

1988

Author dc:creator

• Symes, Jillian Ellis

Advisor dc:contributor.advisor

• Modro, Tomasz A

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/22138

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/22138