Insulin, added to nuclei, stimulates transcription of specific genes
Insulin regulates cellular gene expression and modulates specific mRNA levels in liver cells. As yet, the mechanism of this control is still unclear. The effects are initiated following the binding of insulin to the plasma membrane receptor. Although several mediators of the signal from the plasma membrane to the nucleus have been proposed, none has proved capable of eliciting all of the effects of insulin on gene expression. Therefore, the possibility that insulin itself may directly regulate transcription at the level of the nucleus, was investigated.
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Department of Molecular and Cell Biology