{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/21984"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/21984","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Insulin, added to nuclei, stimulates transcription of specific genes","abstract":"Insulin regulates cellular gene expression and modulates specific mRNA levels in liver cells. As yet, the mechanism of this control is still unclear. The effects are initiated following the binding of insulin to the plasma membrane receptor. Although several mediators of the signal from the plasma membrane to the nucleus have been proposed, none has proved capable of eliciting all of the effects of insulin on gene expression. Therefore, the possibility that insulin itself may directly regulate transcription at the level of the nucleus, was investigated.","abstract_html":"Insulin regulates cellular gene expression and modulates specific mRNA levels in liver cells. As yet, the mechanism of this control is still unclear. The effects are initiated following the binding of insulin to the plasma membrane receptor. Although several mediators of the signal from the plasma membrane to the nucleus have been proposed, none has proved capable of eliciting all of the effects of insulin on gene expression. Therefore, the possibility that insulin itself may directly regulate transcription at the level of the nucleus, was investigated.","abstract_has_math":false,"creators":["Stickells, Brenda Jane"],"institution":"Department of Molecular and Cell Biology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Von Holt, Claus"],"committee_chairs":[],"committee_members":[],"year":1990,"date_issued":"1990","date_published":"1990","updated_at":"2026-07-22T22:23:24Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/21984","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Von Holt, Claus"]},{"key":"dc:creator","label":"Author","values":["Stickells, Brenda Jane"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-09-28T19:05:29Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-09-28T19:05:29Z"]},{"key":"dc:date.issued","label":"Date","values":["1990"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Molecular and Cell Biology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/21984"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bibliography: pages 133-155."]},{"key":"dc:description.abstract","label":"Abstract","values":["Insulin regulates cellular gene expression and modulates specific mRNA levels in liver cells. As yet, the mechanism of this control is still unclear. The effects are initiated following the binding of insulin to the plasma membrane receptor. Although several mediators of the signal from the plasma membrane to the nucleus have been proposed, none has proved capable of eliciting all of the effects of insulin on gene expression. Therefore, the possibility that insulin itself may directly regulate transcription at the level of the nucleus, was investigated."]},{"key":"dc:title","label":"Title","values":["Insulin, added to nuclei, stimulates transcription of specific genes"]}]}],"canonical_facts":{"dc:contributor.advisor":["Von Holt, Claus"],"dc:creator":["Stickells, Brenda Jane"],"dc:date.accessioned":["2016-09-28T19:05:29Z"],"dc:date.available":["2016-09-28T19:05:29Z"],"dc:date.issued":["1990"],"dc:description":["Bibliography: pages 133-155."],"dc:description.abstract":["Insulin regulates cellular gene expression and modulates specific mRNA levels in liver cells. As yet, the mechanism of this control is still unclear. The effects are initiated following the binding of insulin to the plasma membrane receptor. Although several mediators of the signal from the plasma membrane to the nucleus have been proposed, none has proved capable of eliciting all of the effects of insulin on gene expression. Therefore, the possibility that insulin itself may directly regulate transcription at the level of the nucleus, was investigated."],"dc:identifier.uri":["http://hdl.handle.net/11427/21984"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Molecular and Cell Biology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Insulin, added to nuclei, stimulates transcription of specific genes"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:24Z"}