{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/21853"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/21853","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Phytochemical studies on traditional medicinal plants with antimalarial activities","abstract":"The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51)); one flavonoid ( 5-Hydroxy:.4' ,6, 7-trimethoxyflavone ( 44)) and one flavonolignan ( 11-0- acetyl hydnocarpin (62)). In addition, one analogue of 7α-hydroxyroyleanone (41) (which was previously isolated from T riparia and was found to be the active antimalarial principle of the plant) was prepared.","abstract_html":"The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51)); one flavonoid ( 5-Hydroxy:.4' ,6, 7-trimethoxyflavone ( 44)) and one flavonolignan ( 11-0- acetyl hydnocarpin (62)). In addition, one analogue of 7α-hydroxyroyleanone (41) (which was previously isolated from T riparia and was found to be the active antimalarial principle of the plant) was prepared.","abstract_has_math":false,"creators":["Chen, Dianne Tzu-Hsiu"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Gammon, David W","Campbell, William E"],"committee_chairs":[],"committee_members":[],"year":1997,"date_issued":"1997","date_published":"1997","updated_at":"2026-07-22T22:23:04Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/21853","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Gammon, David W","Campbell, William E"]},{"key":"dc:creator","label":"Author","values":["Chen, Dianne Tzu-Hsiu"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-09-20T12:35:23Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-09-20T12:35:23Z"]},{"key":"dc:date.issued","label":"Date","values":["1997"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/21853"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51)); one flavonoid ( 5-Hydroxy:.4' ,6, 7-trimethoxyflavone ( 44)) and one flavonolignan ( 11-0- acetyl hydnocarpin (62)). In addition, one analogue of 7α-hydroxyroyleanone (41) (which was previously isolated from T riparia and was found to be the active antimalarial principle of the plant) was prepared."]},{"key":"dc:title","label":"Title","values":["Phytochemical studies on traditional medicinal plants with antimalarial activities"]}]}],"canonical_facts":{"dc:contributor.advisor":["Gammon, David W","Campbell, William E"],"dc:creator":["Chen, Dianne Tzu-Hsiu"],"dc:date.accessioned":["2016-09-20T12:35:23Z"],"dc:date.available":["2016-09-20T12:35:23Z"],"dc:date.issued":["1997"],"dc:description.abstract":["The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51)); one flavonoid ( 5-Hydroxy:.4' ,6, 7-trimethoxyflavone ( 44)) and one flavonolignan ( 11-0- acetyl hydnocarpin (62)). In addition, one analogue of 7α-hydroxyroyleanone (41) (which was previously isolated from T riparia and was found to be the active antimalarial principle of the plant) was prepared."],"dc:identifier.uri":["http://hdl.handle.net/11427/21853"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Phytochemical studies on traditional medicinal plants with antimalarial activities"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:04Z"}