Computational biomechanics in the remodelling rat heart post myocardial infarction

Cardiovascular diseases account for one third of all deaths worldwide, more than 33% of which are related to ischemic heart disease, including myocardial infarction (MI). This thesis seeks to provide insight and understanding of mechanisms during different stages of MI by utilizing finite element (FE) modelling. Three-dimensional biventricular rat heart geometries were developed from cardiac magnetic resonance images of a healthy heart and a heart with left ventricular (LV) infarction two weeks and four weeks after infarct induction. From these geometries, FE models were established. To represent the myocardium, a structure-based constitutive model and a rule-based myofibre distribution were developed to simulate both passive mechanics and active contraction.

Grantor dc:publisher.institution

Division of Cardiology

Year dc:date.issued

2016

Author dc:creator

• Masithulela, Fulufhelo James

Advisors dc:contributor.advisor

• Franz , Thomas
• Davies, Neil
• Dubuis, Laura

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/20555

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/20555