{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/20500"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/20500","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Towards nuclear imaging with polynuclear radiotracers : the development of monomeric and dendritic scaffolds for radiometals","abstract":"A series of 1,4-diaminobutane poly(propylene amine) (DAB-PPI) dendrimer-based ligands were prepared with the aim of developing ligands that will permit the synthesis of multinuclear technetium-99m (99mTc) radiolabeled complexes. The ligands were synthesized by incorporating N,N-donor atom functionalities, at the periphery of DAB-PPI dendrimers, as potential 99mTc chelates. Monomeric ligands were also synthesized as model compounds to aid with the characterization of macromolecular structures. The first (DAB-G1dendr-(NH2)4) and second (DAB-G2dendr-(NH2)8) generation DAB-PPI peripheral amine end-groups were functionalized using appropriate aldehydes, bearing either 2,2'-bipyridyl or 2-picolylamino entities, via a single step reductive amination reaction. The monomeric and new dendritic ligands were comprehensively characterized using spectroscopic (1H NMR, 13C{1H} NMR, infrared) and analytical techniques (mass spectrometry and elemental analysis). Furthermore, the 2-picolylamino-functionalized ligands were found to be water-soluble, S25 °C = 0.01 mg/μL. A series of non-radioactive ('cold') neutral mononuclear and novel multinuclear dendritic rhenium(I) complexes of the form fac-[Ren(CO)3(N,N-bidentate)Xn] (n = 1, 4 and 8 for monomer, G1 and G2, respectively. X = Cl- or Br-) were prepared and characterized. The complexes with the fac-[Re(CO)3Br] core were synthesized at room temperature using the (Et4N)[Re(CO)3Br3]. One of the 2-picolylamino monomeric complexes, fac-[Re(CO)3(N,N-bidentate)Br], was additionally characterized by X-ray crystallography and the crystallographic structure confirms the facial arrangement of the three CO ligands together with the pseudo octahedral geometry around the metal centre.","abstract_html":"A series of 1,4-diaminobutane poly(propylene amine) (DAB-PPI) dendrimer-based ligands were prepared with the aim of developing ligands that will permit the synthesis of multinuclear technetium-99m (99mTc) radiolabeled complexes. The ligands were synthesized by incorporating N,N-donor atom functionalities, at the periphery of DAB-PPI dendrimers, as potential 99mTc chelates. Monomeric ligands were also synthesized as model compounds to aid with the characterization of macromolecular structures. The first (DAB-G1dendr-(NH2)4) and second (DAB-G2dendr-(NH2)8) generation DAB-PPI peripheral amine end-groups were functionalized using appropriate aldehydes, bearing either 2,2'-bipyridyl or 2-picolylamino entities, via a single step reductive amination reaction. The monomeric and new dendritic ligands were comprehensively characterized using spectroscopic (1H NMR, 13C{1H} NMR, infrared) and analytical techniques (mass spectrometry and elemental analysis). Furthermore, the 2-picolylamino-functionalized ligands were found to be water-soluble, S25 °C = 0.01 mg/μL. A series of non-radioactive ('cold') neutral mononuclear and novel multinuclear dendritic rhenium(I) complexes of the form fac-[Ren(CO)3(N,N-bidentate)Xn] (n = 1, 4 and 8 for monomer, G1 and G2, respectively. X = Cl- or Br-) were prepared and characterized. The complexes with the fac-[Re(CO)3Br] core were synthesized at room temperature using the (Et4N)[Re(CO)3Br3]. One of the 2-picolylamino monomeric complexes, fac-[Re(CO)3(N,N-bidentate)Br], was additionally characterized by X-ray crystallography and the crystallographic structure confirms the facial arrangement of the three CO ligands together with the pseudo octahedral geometry around the metal centre.","abstract_has_math":false,"creators":["Malaza, Siphelele"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Smith, Gregory S","Visser, Hendrik G"],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-07-22T22:23:29Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/20500","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Smith, Gregory S","Visser, Hendrik G"]},{"key":"dc:creator","label":"Author","values":["Malaza, Siphelele"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-07-20T07:01:41Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-07-20T07:01:41Z"]},{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/20500"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A series of 1,4-diaminobutane poly(propylene amine) (DAB-PPI) dendrimer-based ligands were prepared with the aim of developing ligands that will permit the synthesis of multinuclear technetium-99m (99mTc) radiolabeled complexes. The ligands were synthesized by incorporating N,N-donor atom functionalities, at the periphery of DAB-PPI dendrimers, as potential 99mTc chelates. Monomeric ligands were also synthesized as model compounds to aid with the characterization of macromolecular structures. The first (DAB-G1dendr-(NH2)4) and second (DAB-G2dendr-(NH2)8) generation DAB-PPI peripheral amine end-groups were functionalized using appropriate aldehydes, bearing either 2,2'-bipyridyl or 2-picolylamino entities, via a single step reductive amination reaction. The monomeric and new dendritic ligands were comprehensively characterized using spectroscopic (1H NMR, 13C{1H} NMR, infrared) and analytical techniques (mass spectrometry and elemental analysis). Furthermore, the 2-picolylamino-functionalized ligands were found to be water-soluble, S25 °C = 0.01 mg/μL. A series of non-radioactive ('cold') neutral mononuclear and novel multinuclear dendritic rhenium(I) complexes of the form fac-[Ren(CO)3(N,N-bidentate)Xn] (n = 1, 4 and 8 for monomer, G1 and G2, respectively. X = Cl- or Br-) were prepared and characterized. The complexes with the fac-[Re(CO)3Br] core were synthesized at room temperature using the (Et4N)[Re(CO)3Br3]. One of the 2-picolylamino monomeric complexes, fac-[Re(CO)3(N,N-bidentate)Br], was additionally characterized by X-ray crystallography and the crystallographic structure confirms the facial arrangement of the three CO ligands together with the pseudo octahedral geometry around the metal centre."]},{"key":"dc:title","label":"Title","values":["Towards nuclear imaging with polynuclear radiotracers : the development of monomeric and dendritic scaffolds for radiometals"]}]}],"canonical_facts":{"dc:contributor.advisor":["Smith, Gregory S","Visser, Hendrik G"],"dc:creator":["Malaza, Siphelele"],"dc:date.accessioned":["2016-07-20T07:01:41Z"],"dc:date.available":["2016-07-20T07:01:41Z"],"dc:date.issued":["2016"],"dc:description.abstract":["A series of 1,4-diaminobutane poly(propylene amine) (DAB-PPI) dendrimer-based ligands were prepared with the aim of developing ligands that will permit the synthesis of multinuclear technetium-99m (99mTc) radiolabeled complexes. The ligands were synthesized by incorporating N,N-donor atom functionalities, at the periphery of DAB-PPI dendrimers, as potential 99mTc chelates. Monomeric ligands were also synthesized as model compounds to aid with the characterization of macromolecular structures. The first (DAB-G1dendr-(NH2)4) and second (DAB-G2dendr-(NH2)8) generation DAB-PPI peripheral amine end-groups were functionalized using appropriate aldehydes, bearing either 2,2'-bipyridyl or 2-picolylamino entities, via a single step reductive amination reaction. The monomeric and new dendritic ligands were comprehensively characterized using spectroscopic (1H NMR, 13C{1H} NMR, infrared) and analytical techniques (mass spectrometry and elemental analysis). Furthermore, the 2-picolylamino-functionalized ligands were found to be water-soluble, S25 °C = 0.01 mg/μL. A series of non-radioactive ('cold') neutral mononuclear and novel multinuclear dendritic rhenium(I) complexes of the form fac-[Ren(CO)3(N,N-bidentate)Xn] (n = 1, 4 and 8 for monomer, G1 and G2, respectively. X = Cl- or Br-) were prepared and characterized. The complexes with the fac-[Re(CO)3Br] core were synthesized at room temperature using the (Et4N)[Re(CO)3Br3]. One of the 2-picolylamino monomeric complexes, fac-[Re(CO)3(N,N-bidentate)Br], was additionally characterized by X-ray crystallography and the crystallographic structure confirms the facial arrangement of the three CO ligands together with the pseudo octahedral geometry around the metal centre."],"dc:identifier.uri":["http://hdl.handle.net/11427/20500"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Towards nuclear imaging with polynuclear radiotracers : the development of monomeric and dendritic scaffolds for radiometals"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:29Z"}