Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children

Introduction: There are limited data on the chest X-ray (CXR) abnormalities in human immunodeficiency virus (HIV)-infected children in low- and middle-income countries (LMIC's). Aim: To investigate the evolution of CXR abnormalities in HIV-infected children in LMIC's, to correlate this with the severity of HIV-disease, and to assess the impact of anti-retroviral therapy (ART). Method: A prospective longitudinal study evaluating clinical, immunological and radiographic parameters at regular intervals over a minimum of 24 months. CXR abnormalities were stratified by severity and deemed persistent if present for 6 consecutive months or longer. Univariate and multiple logistic regression analyses assessed associations between radiological and clinical/immunological parameters at enrolment. An ordinal multiple logistic regression model assessed the association of enrolment and time-dependent variables with CXR findings over time.

Grantor dc:publisher.institution

Department of Paediatrics and Child Health

Year dc:date.issued

2016

Author dc:creator

• Pitcher, Richard D

Advisor dc:contributor.advisor

• Zar, Heather

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/20351

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/20351