{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/20303"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/20303","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes","abstract":"Over the past few decades metals in medicine have played to play a significant role, especially after the discovery of the anticancer properties of cisplatin. However, acquired and intrinsic resistance, toxicity and a host of side-effects have encouraged the research for new metal based anticancer agents. Organometallic complexes have proved to be successful anticancer agents and several have commenced clinical trials. The aim of this study was to prepare and characterize trinuclear platinum group organometallic complexes and investigate their in vitro activity. The first series of ester containing complexes were prepared. The ligands were generated by the preparation of Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either benzaldehyde, 2-pyridinecarboxaldehyde or salicylaldehyde. Trimeric ester ligands were prepared from these monomeric ligands by reaction with trimesoyl chloride.","abstract_html":"Over the past few decades metals in medicine have played to play a significant role, especially after the discovery of the anticancer properties of cisplatin. However, acquired and intrinsic resistance, toxicity and a host of side-effects have encouraged the research for new metal based anticancer agents. Organometallic complexes have proved to be successful anticancer agents and several have commenced clinical trials. The aim of this study was to prepare and characterize trinuclear platinum group organometallic complexes and investigate their in vitro activity. The first series of ester containing complexes were prepared. The ligands were generated by the preparation of Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either benzaldehyde, 2-pyridinecarboxaldehyde or salicylaldehyde. Trimeric ester ligands were prepared from these monomeric ligands by reaction with trimesoyl chloride.","abstract_has_math":false,"creators":["Burgoyne, Andrew R"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Smith, Gregory S"],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-07-22T22:23:07Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/20303","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Smith, Gregory S"]},{"key":"dc:creator","label":"Author","values":["Burgoyne, Andrew R"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-07-11T13:53:39Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-07-11T13:53:39Z"]},{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/20303"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Over the past few decades metals in medicine have played to play a significant role, especially after the discovery of the anticancer properties of cisplatin. However, acquired and intrinsic resistance, toxicity and a host of side-effects have encouraged the research for new metal based anticancer agents. Organometallic complexes have proved to be successful anticancer agents and several have commenced clinical trials. The aim of this study was to prepare and characterize trinuclear platinum group organometallic complexes and investigate their in vitro activity. The first series of ester containing complexes were prepared. The ligands were generated by the preparation of Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either benzaldehyde, 2-pyridinecarboxaldehyde or salicylaldehyde. Trimeric ester ligands were prepared from these monomeric ligands by reaction with trimesoyl chloride."]},{"key":"dc:title","label":"Title","values":["Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes"]}]}],"canonical_facts":{"dc:contributor.advisor":["Smith, Gregory S"],"dc:creator":["Burgoyne, Andrew R"],"dc:date.accessioned":["2016-07-11T13:53:39Z"],"dc:date.available":["2016-07-11T13:53:39Z"],"dc:date.issued":["2016"],"dc:description.abstract":["Over the past few decades metals in medicine have played to play a significant role, especially after the discovery of the anticancer properties of cisplatin. However, acquired and intrinsic resistance, toxicity and a host of side-effects have encouraged the research for new metal based anticancer agents. Organometallic complexes have proved to be successful anticancer agents and several have commenced clinical trials. The aim of this study was to prepare and characterize trinuclear platinum group organometallic complexes and investigate their in vitro activity. The first series of ester containing complexes were prepared. The ligands were generated by the preparation of Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either benzaldehyde, 2-pyridinecarboxaldehyde or salicylaldehyde. Trimeric ester ligands were prepared from these monomeric ligands by reaction with trimesoyl chloride."],"dc:identifier.uri":["http://hdl.handle.net/11427/20303"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:07Z"}