The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes

This thesis comprises a report of investigations into the interaction of the volatile anaesthetic agents, fluroxene, 2,2,2-trifluoroethyl ethyl ether(TFEE), methoxyflurane and enflurane, with hepatic drug metabolizing enzymes in vivo and in vitro. Each of the anaesthetic agents interacts with the type P-450 cytochromes of hepatic microsomes in vitro resulting in the appearance of a type I difference spectrum, enhancement of NADPH oxidation and production of potentially toxic metabolites, 2,2,2-trifluoroethanol (TFE) (from fluroxene and TFEE) and free fluoride ion (from methoxyflurane and enflurane).

Grantor dc:publisher.institution

Division of Medical Biochemistry

Year dc:date.issued

1977

Author dc:creator

• Marsh, Julia Anne

Advisor dc:contributor.advisor

• Ivanetich, Kathryn

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/18081

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/18081