{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/17406"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/17406","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Disruption of microorganisms due to agitation in slurries of fine particles","abstract":"This dissertation presents the results of an investigation into the disruption of microorganisms when agitated in slurries of fine particles in a stirred tank. The most widely used industrial process involving agitation of microorganisms in slurries of particles in stirred tanks is the biooxidation process. Mixed cultures of thiobacilli are used in stirred tank reactors for the biooxidation of sulphide minerals. In addition to operating conditions, the efficiency of biotechnological processes is dependent on the growth and metabolism of the microorganisms. The microorganisms are sensitive to the hydrodynamic conditions generated in the processes. In response to adverse hydrodynamic conditions there may be changes in the growth rate of the microorganisms, the nutrient uptake rate, the product formation rate and morphology of the microorganisms. Under extreme conditions cell damage and disruption may ensue. The presence of particulates in bioprocesses, in the form of solid substrates or support systems for attached growth, further complicate the hydrodynamic conditions. The knowledge of the effect of particulates on microorganisms is an important priority.","abstract_html":"This dissertation presents the results of an investigation into the disruption of microorganisms when agitated in slurries of fine particles in a stirred tank. The most widely used industrial process involving agitation of microorganisms in slurries of particles in stirred tanks is the biooxidation process. Mixed cultures of thiobacilli are used in stirred tank reactors for the biooxidation of sulphide minerals. In addition to operating conditions, the efficiency of biotechnological processes is dependent on the growth and metabolism of the microorganisms. The microorganisms are sensitive to the hydrodynamic conditions generated in the processes. In response to adverse hydrodynamic conditions there may be changes in the growth rate of the microorganisms, the nutrient uptake rate, the product formation rate and morphology of the microorganisms. Under extreme conditions cell damage and disruption may ensue. The presence of particulates in bioprocesses, in the form of solid substrates or support systems for attached growth, further complicate the hydrodynamic conditions. The knowledge of the effect of particulates on microorganisms is an important priority.","abstract_has_math":false,"creators":["Pearce, Sarah Jane Amanda"],"institution":"Department of Chemical Engineering","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Harrison, STL","Hansford, Geoffrey Spearing"],"committee_chairs":[],"committee_members":[],"year":1993,"date_issued":"1993","date_published":"1993","updated_at":"2026-07-22T22:23:02Z","subjects":["Bioprocess Engineering"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/17406","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Harrison, STL","Hansford, Geoffrey Spearing"]},{"key":"dc:creator","label":"Author","values":["Pearce, Sarah Jane Amanda"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-03-01T07:44:42Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-03-01T07:44:42Z"]},{"key":"dc:date.issued","label":"Date","values":["1993"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemical Engineering"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Bioprocess Engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/17406"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bibliography: pages 149-155."]},{"key":"dc:description.abstract","label":"Abstract","values":["This dissertation presents the results of an investigation into the disruption of microorganisms when agitated in slurries of fine particles in a stirred tank. The most widely used industrial process involving agitation of microorganisms in slurries of particles in stirred tanks is the biooxidation process. Mixed cultures of thiobacilli are used in stirred tank reactors for the biooxidation of sulphide minerals. In addition to operating conditions, the efficiency of biotechnological processes is dependent on the growth and metabolism of the microorganisms. The microorganisms are sensitive to the hydrodynamic conditions generated in the processes. In response to adverse hydrodynamic conditions there may be changes in the growth rate of the microorganisms, the nutrient uptake rate, the product formation rate and morphology of the microorganisms. Under extreme conditions cell damage and disruption may ensue. The presence of particulates in bioprocesses, in the form of solid substrates or support systems for attached growth, further complicate the hydrodynamic conditions. The knowledge of the effect of particulates on microorganisms is an important priority."]},{"key":"dc:title","label":"Title","values":["Disruption of microorganisms due to agitation in slurries of fine particles"]}]}],"canonical_facts":{"dc:contributor.advisor":["Harrison, STL","Hansford, Geoffrey Spearing"],"dc:creator":["Pearce, Sarah Jane Amanda"],"dc:date.accessioned":["2016-03-01T07:44:42Z"],"dc:date.available":["2016-03-01T07:44:42Z"],"dc:date.issued":["1993"],"dc:description":["Bibliography: pages 149-155."],"dc:description.abstract":["This dissertation presents the results of an investigation into the disruption of microorganisms when agitated in slurries of fine particles in a stirred tank. The most widely used industrial process involving agitation of microorganisms in slurries of particles in stirred tanks is the biooxidation process. Mixed cultures of thiobacilli are used in stirred tank reactors for the biooxidation of sulphide minerals. In addition to operating conditions, the efficiency of biotechnological processes is dependent on the growth and metabolism of the microorganisms. The microorganisms are sensitive to the hydrodynamic conditions generated in the processes. In response to adverse hydrodynamic conditions there may be changes in the growth rate of the microorganisms, the nutrient uptake rate, the product formation rate and morphology of the microorganisms. Under extreme conditions cell damage and disruption may ensue. The presence of particulates in bioprocesses, in the form of solid substrates or support systems for attached growth, further complicate the hydrodynamic conditions. The knowledge of the effect of particulates on microorganisms is an important priority."],"dc:identifier.uri":["http://hdl.handle.net/11427/17406"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemical Engineering"],"dc:publisher.institution":["University of Cape Town"],"dc:subject":["Bioprocess Engineering"],"dc:title":["Disruption of microorganisms due to agitation in slurries of fine particles"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:02Z"}