The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes

Reciprocal modulation between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone (GnRH) signalling pathways is a potential mechanism for integrating cellular responses to stress with reproductive function. This study investigated if membrane rafts play a role in GR and GnRH receptor (GnRHR) crosstalk and explored the mechanism involved in the mouse pituitary gonadotrope LβT2 cell line by dexamethasone (Dex), GnRH and both together.

Grantor dc:publisher.institution

Department of English Language and Literature

Year dc:date.issued

2015

Author dc:creator

• Wehmeyer, Lance

Advisor dc:contributor.advisor

• Hapgood, Janet P

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/16934

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/16934