{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/16864"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/16864","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape","abstract":"Objective: To establish whether there is an association between HIV exposure and infectious disease mortality in children admitted to hospital in the Western Cape. Also to identify additional risk factors associated with mortality and the prevalence of HIV exposure. Methods: A case-control design was used to compare the HIV exposure status of 93 cases admitted with an infectious disease who died with 93 controls admitted with an infectious disease who did not die. Clinical and demographic data were collected via record review at three hospitals in the Western Cape . Factors associated with mortality were identified through regression analysis. Findings: 38.71% (36/93) of cases were HIV exposed versus 22.58% (21/93) of controls (p=0.017). 32.36% (30/93) of cases were HIV exposed uninfected (HEU) versus 18.28% (17/93) of controls (p=0.06). Being HEU was a risk factor for mortality after adjusting for age, sex, feeding practice, and main infection. The odds of death in HEU children was 2.29 times greater than in HUU (aOR: 2.29, 95% CI: 1.06-5.0). Age, sex, and feeding practice confounded the association between HIV exposure-infection and mortality. LRTI, septicaemia, and meningitis were all significantly associated with mortality at the 5% level. Children admitted with septicaemia demonstrated a 13.44 times increased odds of death (aOR: 13.44, 95% CI: 3.35-53.99). Conclusion: Children born to HIV positive mothers should be considered a vulnerable group even if vertical transmission has been prevented. Determination of exposure status could be a valuable tool for identifying children at increased risk of death. Septicaemia and meningitis also present a challenge in critical care in our sample.","abstract_html":"Objective: To establish whether there is an association between HIV exposure and infectious disease mortality in children admitted to hospital in the Western Cape. Also to identify additional risk factors associated with mortality and the prevalence of HIV exposure. Methods: A case-control design was used to compare the HIV exposure status of 93 cases admitted with an infectious disease who died with 93 controls admitted with an infectious disease who did not die. Clinical and demographic data were collected via record review at three hospitals in the Western Cape . Factors associated with mortality were identified through regression analysis. Findings: 38.71% (36/93) of cases were HIV exposed versus 22.58% (21/93) of controls (p=0.017). 32.36% (30/93) of cases were HIV exposed uninfected (HEU) versus 18.28% (17/93) of controls (p=0.06). Being HEU was a risk factor for mortality after adjusting for age, sex, feeding practice, and main infection. The odds of death in HEU children was 2.29 times greater than in HUU (aOR: 2.29, 95% CI: 1.06-5.0). Age, sex, and feeding practice confounded the association between HIV exposure-infection and mortality. LRTI, septicaemia, and meningitis were all significantly associated with mortality at the 5% level. Children admitted with septicaemia demonstrated a 13.44 times increased odds of death (aOR: 13.44, 95% CI: 3.35-53.99). Conclusion: Children born to HIV positive mothers should be considered a vulnerable group even if vertical transmission has been prevented. Determination of exposure status could be a valuable tool for identifying children at increased risk of death. Septicaemia and meningitis also present a challenge in critical care in our sample.","abstract_has_math":false,"creators":["Reed, Robert Anthony"],"institution":"Department of Public Health and Family Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Coetzee, David"],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015","date_published":"2015","updated_at":"2026-07-22T22:22:41Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/16864","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Coetzee, David"]},{"key":"dc:creator","label":"Author","values":["Reed, Robert Anthony"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-02-08T07:20:11Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-02-08T07:20:11Z"]},{"key":"dc:date.issued","label":"Date","values":["2015"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Public Health and Family Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MPH"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/16864"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references"]},{"key":"dc:description.abstract","label":"Abstract","values":["Objective: To establish whether there is an association between HIV exposure and infectious disease mortality in children admitted to hospital in the Western Cape. Also to identify additional risk factors associated with mortality and the prevalence of HIV exposure. Methods: A case-control design was used to compare the HIV exposure status of 93 cases admitted with an infectious disease who died with 93 controls admitted with an infectious disease who did not die. Clinical and demographic data were collected via record review at three hospitals in the Western Cape . Factors associated with mortality were identified through regression analysis. Findings: 38.71% (36/93) of cases were HIV exposed versus 22.58% (21/93) of controls (p=0.017). 32.36% (30/93) of cases were HIV exposed uninfected (HEU) versus 18.28% (17/93) of controls (p=0.06). Being HEU was a risk factor for mortality after adjusting for age, sex, feeding practice, and main infection. The odds of death in HEU children was 2.29 times greater than in HUU (aOR: 2.29, 95% CI: 1.06-5.0). Age, sex, and feeding practice confounded the association between HIV exposure-infection and mortality. LRTI, septicaemia, and meningitis were all significantly associated with mortality at the 5% level. Children admitted with septicaemia demonstrated a 13.44 times increased odds of death (aOR: 13.44, 95% CI: 3.35-53.99). Conclusion: Children born to HIV positive mothers should be considered a vulnerable group even if vertical transmission has been prevented. Determination of exposure status could be a valuable tool for identifying children at increased risk of death. Septicaemia and meningitis also present a challenge in critical care in our sample."]},{"key":"dc:title","label":"Title","values":["An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape"]}]}],"canonical_facts":{"dc:contributor.advisor":["Coetzee, David"],"dc:creator":["Reed, Robert Anthony"],"dc:date.accessioned":["2016-02-08T07:20:11Z"],"dc:date.available":["2016-02-08T07:20:11Z"],"dc:date.issued":["2015"],"dc:description":["Includes bibliographical references"],"dc:description.abstract":["Objective: To establish whether there is an association between HIV exposure and infectious disease mortality in children admitted to hospital in the Western Cape. Also to identify additional risk factors associated with mortality and the prevalence of HIV exposure. Methods: A case-control design was used to compare the HIV exposure status of 93 cases admitted with an infectious disease who died with 93 controls admitted with an infectious disease who did not die. Clinical and demographic data were collected via record review at three hospitals in the Western Cape . Factors associated with mortality were identified through regression analysis. Findings: 38.71% (36/93) of cases were HIV exposed versus 22.58% (21/93) of controls (p=0.017). 32.36% (30/93) of cases were HIV exposed uninfected (HEU) versus 18.28% (17/93) of controls (p=0.06). Being HEU was a risk factor for mortality after adjusting for age, sex, feeding practice, and main infection. The odds of death in HEU children was 2.29 times greater than in HUU (aOR: 2.29, 95% CI: 1.06-5.0). Age, sex, and feeding practice confounded the association between HIV exposure-infection and mortality. LRTI, septicaemia, and meningitis were all significantly associated with mortality at the 5% level. Children admitted with septicaemia demonstrated a 13.44 times increased odds of death (aOR: 13.44, 95% CI: 3.35-53.99). Conclusion: Children born to HIV positive mothers should be considered a vulnerable group even if vertical transmission has been prevented. Determination of exposure status could be a valuable tool for identifying children at increased risk of death. Septicaemia and meningitis also present a challenge in critical care in our sample."],"dc:identifier.uri":["http://hdl.handle.net/11427/16864"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Public Health and Family Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MPH"]},"updated_at":"2026-07-22T22:22:41Z"}