The relationship between neurocognitive disorders, prospective memory impairment and white matter damage in clade C HIV-positive subjects

AIMS: To examine the relationship between prospective memory, cognitive function and Diffusion tensor imaging (DTI)/ White matter integrity of human immunodeficiency virus (HIV) positive individuals in the Western Cape. We hypothesize that: 1. Individuals infected with HIV will exhibit significantly poorer microstructural integrity of the white matter than HIV negative individuals, as determined by in vivo diffusion tensor imaging. We expect that values of fractional anisotropy (FA) - a measure of directional water diffusion- in the frontal white matter will be significantly lower among HIV patients compared to controls 2. Lower FA measured in the frontal white matter will correlate significantly with impaired performance on tests of prospective memory

Grantor dc:publisher.institution

Division of Neuropsychiatry

Year dc:date.issued

2010

Author dc:creator

• Hoare, Jacqueline

Advisors dc:contributor.advisor

• Joska, John Anton
• Stein, Dan J

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/14734

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/14734