{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/13243"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/13243","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Prevalence of Hepatitis B in HIV infected persons: choice of antiretroviral therapy regimen and implications for screening","abstract":"Limited data and few studies have shown the prevalence of Hepatitis B in the HIV infected population in South Africa, whether these patients are on appropriate antiretroviral therapy and the effect of Hepatitis B on liver function in co-infected persons. The objectives of this study were to determine the prevalence of Hepatitis B surface antigemia (HBsAg) in healthy HIV positive persons screened for a vaccine trial and the proportion of those eligible for antiretroviral therapy that were receiving optimal antiviral treatment, namely tenofovir and/or lamivudine. The relationship between Hepatitis B carriage and liver function was also determined in co-infected persons as measured by liver function tests. A cross sectional study was conducted from 30th August 2011 to 24th April 2013 to determine the prevalence of HIV /HBV co-infection in persons attending a clinical trial site in an urban clinical trials unit of Cape Town. Participants self-presented to the clinic and once consented were enrolled into the study and provided blood for HIV confirmatory test, Hepatitis B sAg, CD4, VL, full blood count, liver function and renal function tests. 638 participants were enrolled into this cross sectional study. 24 (3.8%) were Hepatitis B sAg positive, which was lower than expected. Of the 24 HIV/HBV co-infected participants, 19 (79 .2%) were on antiretroviral therapy, 14 (73. 7%) of these were on a tenofovir/lamivudine regimen the remaining 5 (26.3%) were not on a tenofovir regimen. Five of the co-infected participants were not on ARVs because their CD4 count was above the recommended South African guidelines for treatment i.e. greater than 350 1 QA6/l. Male participants were three times more likely to be HBsAg positive. Elevated Alanine aminotransferase (ALT) and Aspartate Aminotransferase (AST) were associated with HBsAg seropositivity. This study showed a lower HIV /HBV co-infection prevalence rate than reported from other locations in South Africa suggesting geographical variability. Appropriate guidelines are required to ensure that co-infected patients are identified and treated with the most appropriate anti-retroviral regimens. Screening for HBV is also recommended in HIV infected cohorts.","abstract_html":"Limited data and few studies have shown the prevalence of Hepatitis B in the HIV infected population in South Africa, whether these patients are on appropriate antiretroviral therapy and the effect of Hepatitis B on liver function in co-infected persons. The objectives of this study were to determine the prevalence of Hepatitis B surface antigemia (HBsAg) in healthy HIV positive persons screened for a vaccine trial and the proportion of those eligible for antiretroviral therapy that were receiving optimal antiviral treatment, namely tenofovir and/or lamivudine. The relationship between Hepatitis B carriage and liver function was also determined in co-infected persons as measured by liver function tests. A cross sectional study was conducted from 30th August 2011 to 24th April 2013 to determine the prevalence of HIV /HBV co-infection in persons attending a clinical trial site in an urban clinical trials unit of Cape Town. Participants self-presented to the clinic and once consented were enrolled into the study and provided blood for HIV confirmatory test, Hepatitis B sAg, CD4, VL, full blood count, liver function and renal function tests. 638 participants were enrolled into this cross sectional study. 24 (3.8%) were Hepatitis B sAg positive, which was lower than expected. Of the 24 HIV/HBV co-infected participants, 19 (79 .2%) were on antiretroviral therapy, 14 (73. 7%) of these were on a tenofovir/lamivudine regimen the remaining 5 (26.3%) were not on a tenofovir regimen. Five of the co-infected participants were not on ARVs because their CD4 count was above the recommended South African guidelines for treatment i.e. greater than 350 1 QA6/l. Male participants were three times more likely to be HBsAg positive. Elevated Alanine aminotransferase (ALT) and Aspartate Aminotransferase (AST) were associated with HBsAg seropositivity. This study showed a lower HIV /HBV co-infection prevalence rate than reported from other locations in South Africa suggesting geographical variability. Appropriate guidelines are required to ensure that co-infected patients are identified and treated with the most appropriate anti-retroviral regimens. Screening for HBV is also recommended in HIV infected cohorts.","abstract_has_math":false,"creators":["Reidy, Derval"],"institution":"Department of Public Health and Family Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Coetzee, David"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-22T22:23:05Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/13243","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Coetzee, David"]},{"key":"dc:creator","label":"Author","values":["Reidy, Derval"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-07-01T09:02:17Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-07-01T09:02:17Z"]},{"key":"dc:date.issued","label":"Date","values":["2014"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Public Health and Family Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MPH"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/13243"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Limited data and few studies have shown the prevalence of Hepatitis B in the HIV infected population in South Africa, whether these patients are on appropriate antiretroviral therapy and the effect of Hepatitis B on liver function in co-infected persons. The objectives of this study were to determine the prevalence of Hepatitis B surface antigemia (HBsAg) in healthy HIV positive persons screened for a vaccine trial and the proportion of those eligible for antiretroviral therapy that were receiving optimal antiviral treatment, namely tenofovir and/or lamivudine. The relationship between Hepatitis B carriage and liver function was also determined in co-infected persons as measured by liver function tests. A cross sectional study was conducted from 30th August 2011 to 24th April 2013 to determine the prevalence of HIV /HBV co-infection in persons attending a clinical trial site in an urban clinical trials unit of Cape Town. Participants self-presented to the clinic and once consented were enrolled into the study and provided blood for HIV confirmatory test, Hepatitis B sAg, CD4, VL, full blood count, liver function and renal function tests. 638 participants were enrolled into this cross sectional study. 24 (3.8%) were Hepatitis B sAg positive, which was lower than expected. Of the 24 HIV/HBV co-infected participants, 19 (79 .2%) were on antiretroviral therapy, 14 (73. 7%) of these were on a tenofovir/lamivudine regimen the remaining 5 (26.3%) were not on a tenofovir regimen. Five of the co-infected participants were not on ARVs because their CD4 count was above the recommended South African guidelines for treatment i.e. greater than 350 1 QA6/l. Male participants were three times more likely to be HBsAg positive. Elevated Alanine aminotransferase (ALT) and Aspartate Aminotransferase (AST) were associated with HBsAg seropositivity. This study showed a lower HIV /HBV co-infection prevalence rate than reported from other locations in South Africa suggesting geographical variability. Appropriate guidelines are required to ensure that co-infected patients are identified and treated with the most appropriate anti-retroviral regimens. Screening for HBV is also recommended in HIV infected cohorts."]},{"key":"dc:title","label":"Title","values":["Prevalence of Hepatitis B in HIV infected persons: choice of antiretroviral therapy regimen and implications for screening"]}]}],"canonical_facts":{"dc:contributor.advisor":["Coetzee, David"],"dc:creator":["Reidy, Derval"],"dc:date.accessioned":["2015-07-01T09:02:17Z"],"dc:date.available":["2015-07-01T09:02:17Z"],"dc:date.issued":["2014"],"dc:description.abstract":["Limited data and few studies have shown the prevalence of Hepatitis B in the HIV infected population in South Africa, whether these patients are on appropriate antiretroviral therapy and the effect of Hepatitis B on liver function in co-infected persons. The objectives of this study were to determine the prevalence of Hepatitis B surface antigemia (HBsAg) in healthy HIV positive persons screened for a vaccine trial and the proportion of those eligible for antiretroviral therapy that were receiving optimal antiviral treatment, namely tenofovir and/or lamivudine. The relationship between Hepatitis B carriage and liver function was also determined in co-infected persons as measured by liver function tests. A cross sectional study was conducted from 30th August 2011 to 24th April 2013 to determine the prevalence of HIV /HBV co-infection in persons attending a clinical trial site in an urban clinical trials unit of Cape Town. Participants self-presented to the clinic and once consented were enrolled into the study and provided blood for HIV confirmatory test, Hepatitis B sAg, CD4, VL, full blood count, liver function and renal function tests. 638 participants were enrolled into this cross sectional study. 24 (3.8%) were Hepatitis B sAg positive, which was lower than expected. Of the 24 HIV/HBV co-infected participants, 19 (79 .2%) were on antiretroviral therapy, 14 (73. 7%) of these were on a tenofovir/lamivudine regimen the remaining 5 (26.3%) were not on a tenofovir regimen. Five of the co-infected participants were not on ARVs because their CD4 count was above the recommended South African guidelines for treatment i.e. greater than 350 1 QA6/l. Male participants were three times more likely to be HBsAg positive. Elevated Alanine aminotransferase (ALT) and Aspartate Aminotransferase (AST) were associated with HBsAg seropositivity. This study showed a lower HIV /HBV co-infection prevalence rate than reported from other locations in South Africa suggesting geographical variability. Appropriate guidelines are required to ensure that co-infected patients are identified and treated with the most appropriate anti-retroviral regimens. Screening for HBV is also recommended in HIV infected cohorts."],"dc:identifier.uri":["http://hdl.handle.net/11427/13243"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Public Health and Family Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Prevalence of Hepatitis B in HIV infected persons: choice of antiretroviral therapy regimen and implications for screening"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MPH"]},"updated_at":"2026-07-22T22:23:05Z"}