An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds

Crushed garlic contains organosulfur compounds (OSC), which are reported to have cancer chemotherapeutic properties both in vitro and in vivo. A library of 15 organosulfur analogues were obtained as mechanistic probes in WHCO1 oesophageal cancer cells. Structure-activity studies showed a positive correlation between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values.

Grantor dc:publisher.institution

Division of Medical Biochemistry

Year dc:date.issued

2014

Author dc:creator

• Smith, Muneerah

Advisors dc:contributor.advisor

• Parker, Iqbal
• Kaschula, Catherine Hart

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/12795

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/12795