A review of living donor liver transplantation: why is regeneration more rapid in the recipient compared to the donor?

Living donor liver transplantation (LDLT) is now well established and performed on a routine basis in many major centres around the world. LDLT is feasible because of the capacity of both the remnant donor liver and the transplanted partial liver to undergo liver regeneration. However it has been demonstrated that liver regeneration in the recipient is rapid, whereas restoration of liver mass in the donor is delayed. This discrepancy in the rate of regeneration could be due to the presence of hepatotrophic factors and the use of immunosuppression in the recipient. The aims of the studies were to determine if hepatotrophic factors and immunosuppression (Cyclosporine) could modify the restoration of the liver mass after partial hepatectomy in rats.

Grantor dc:publisher.institution

Department of Surgery

Year dc:date.issued

2009

Author dc:creator

• Ibirogba, Sheriff B

Advisor dc:contributor.advisor

• Kahn, Delawir

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/12516

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/12516