Metal complexes of penicillin and cephalosporin antibiotics

The interaction between metal-ions and the penicillin and cephalosporin antibiotics have been studied in an attempt to determine both the site and mechanism of this interaction. The solution conformation of the Cu(II) and Mn(II) complexes were determined using an n.m.r, line broadening, technique. The ligands benzylpenicillin, 6-aminopenicillanic acid, cephalothin, cephalexin, ampicillin and thiaproline were used to study the effect of structural changes in the ligand on the structure of the complex. The stability constants of several metal-ions/penicillin complexes were determined potentiometrically. These were correlated with stability constants determined for several related complexes. Finally the kinetics of the Ni(II) substitution reaction with benzylpenicillin, penicilloic acid, ampicillin and thiaproline was studied.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

1975

Author dc:creator

• Jackson, Graham Ellis

Advisors dc:contributor.advisor

• Nassimbeni, Luigi R
• Linder, P W
• Fazakerley, G V

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/12471

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/12471