A study of an animal model of Attention-Deficit/ Hyperactivity Disorder using in vivo chronoamperometry and behavioural responses to methylphenidate and guanfacine

Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood disorder that is behaviorally characterized by developmentally inappropriate levels of inattention, impulsivity and hyperactivity. Among several hypotheses of ADHD etiology the prevailing hypothesis implicates a hypodopaminergic system due largely to the successes of the use of psychostimulants such as methylphenidate, that increase extracellular levels of dopamine (DA) and/or norepinephrine (NE) for the treatment of symptoms. In this study, the spontaneously hypertensive rat (SHR), the most widely accepted model for ADHD, is compared with the Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rat strains as controls

Grantor dc:publisher.institution

MRC/UCT RU for Exercise and Sport Medicine

Year dc:date.issued

2010

Author dc:creator

• Hsin-Wen Hsieh, Jennifer

Advisor dc:contributor.advisor

• Russell, Vivienne A

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/12368

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/12368