{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/12126"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/12126","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Investigation of the antioxidant activity of phenolic compounds in cell culture systems","abstract":"This study focuses on newly synthesized polyphenolic compounds which were expected to be antioxidants in vivo. Antioxidants are compounds which at low concentrations can prevent or reduce the deleterious effects caused by reactive oxygen species (ROS) induced by UVA exposure of the skin. This study focuses on developing methods required to measure the effects of these synthesized compounds in ultraviolet radiation-exposed cultured skin cells. Biocatalytic synthesis of polyphenolic compounds was carried out using isolated enzymes, tyrosinase from Agaricus biosporus, and laccase from Trametes pubescens to produce oxidized oligomeric products.","abstract_html":"This study focuses on newly synthesized polyphenolic compounds which were expected to be antioxidants in vivo. Antioxidants are compounds which at low concentrations can prevent or reduce the deleterious effects caused by reactive oxygen species (ROS) induced by UVA exposure of the skin. This study focuses on developing methods required to measure the effects of these synthesized compounds in ultraviolet radiation-exposed cultured skin cells. Biocatalytic synthesis of polyphenolic compounds was carried out using isolated enzymes, tyrosinase from Agaricus biosporus, and laccase from Trametes pubescens to produce oxidized oligomeric products.","abstract_has_math":false,"creators":["Zwane, Eunice Nonhlanhla"],"institution":"Centre for Bioprocess Engineering Research","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Burton, Stephanie Gail"],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009","date_published":"2009","updated_at":"2026-07-22T22:23:05Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/12126","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Burton, Stephanie Gail"]},{"key":"dc:creator","label":"Author","values":["Zwane, Eunice Nonhlanhla"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-13T04:00:46Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-13T04:00:46Z"]},{"key":"dc:date.issued","label":"Date","values":["2009"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Centre for Bioprocess Engineering Research"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/12126"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes abstract.","Includes bibliographical references (leaves 81-95)."]},{"key":"dc:description.abstract","label":"Abstract","values":["This study focuses on newly synthesized polyphenolic compounds which were expected to be antioxidants in vivo. Antioxidants are compounds which at low concentrations can prevent or reduce the deleterious effects caused by reactive oxygen species (ROS) induced by UVA exposure of the skin. This study focuses on developing methods required to measure the effects of these synthesized compounds in ultraviolet radiation-exposed cultured skin cells. Biocatalytic synthesis of polyphenolic compounds was carried out using isolated enzymes, tyrosinase from Agaricus biosporus, and laccase from Trametes pubescens to produce oxidized oligomeric products."]},{"key":"dc:title","label":"Title","values":["Investigation of the antioxidant activity of phenolic compounds in cell culture systems"]}]}],"canonical_facts":{"dc:contributor.advisor":["Burton, Stephanie Gail"],"dc:creator":["Zwane, Eunice Nonhlanhla"],"dc:date.accessioned":["2015-01-13T04:00:46Z"],"dc:date.available":["2015-01-13T04:00:46Z"],"dc:date.issued":["2009"],"dc:description":["Includes abstract.","Includes bibliographical references (leaves 81-95)."],"dc:description.abstract":["This study focuses on newly synthesized polyphenolic compounds which were expected to be antioxidants in vivo. Antioxidants are compounds which at low concentrations can prevent or reduce the deleterious effects caused by reactive oxygen species (ROS) induced by UVA exposure of the skin. This study focuses on developing methods required to measure the effects of these synthesized compounds in ultraviolet radiation-exposed cultured skin cells. Biocatalytic synthesis of polyphenolic compounds was carried out using isolated enzymes, tyrosinase from Agaricus biosporus, and laccase from Trametes pubescens to produce oxidized oligomeric products."],"dc:identifier.uri":["http://hdl.handle.net/11427/12126"],"dc:language.iso":["eng"],"dc:publisher.department":["Centre for Bioprocess Engineering Research"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Investigation of the antioxidant activity of phenolic compounds in cell culture systems"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:05Z"}