{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/11999"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/11999","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The role of human breast milk mucus and mucins in HIV-AIDS","abstract":"Milk molecules such as mucins, antibodies, bactericidal enzymes like lysozymes and fatty acids that lyse bacteria, viral particles and bacterial peptides, offer anti-microbial activity in milk. Despite human breast milk being rich in anti-microbial substances, such as mucin, that protect against pathogens and viruses, it remains a significant route of HIV transmission from mother to child. ... The objectives of the study were to isolate, purify, identify and investigate the anti-HIV-1 activity of crude breast milk particularly the human milk fat globule material (MFGM) and its purified mucin components, in HIV positive patients (n = 20) compared with those who are not infected (n = 20). This study also tested the effect that heat (80°C, 10 min) might have on breast milk which might release the milk mucins and consequently have an inhibitory effect on HIV-1.","abstract_html":"Milk molecules such as mucins, antibodies, bactericidal enzymes like lysozymes and fatty acids that lyse bacteria, viral particles and bacterial peptides, offer anti-microbial activity in milk. Despite human breast milk being rich in anti-microbial substances, such as mucin, that protect against pathogens and viruses, it remains a significant route of HIV transmission from mother to child. ... The objectives of the study were to isolate, purify, identify and investigate the anti-HIV-1 activity of crude breast milk particularly the human milk fat globule material (MFGM) and its purified mucin components, in HIV positive patients (n = 20) compared with those who are not infected (n = 20). This study also tested the effect that heat (80°C, 10 min) might have on breast milk which might release the milk mucins and consequently have an inhibitory effect on HIV-1.","abstract_has_math":false,"creators":["Mthembu, Yolanda"],"institution":"Department of Surgery","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Mall, Anwar Suleman"],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012","date_published":"2012","updated_at":"2026-07-22T22:23:18Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/11999","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Mall, Anwar Suleman"]},{"key":"dc:creator","label":"Author","values":["Mthembu, Yolanda"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-10T13:38:33Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-10T13:38:33Z"]},{"key":"dc:date.issued","label":"Date","values":["2012"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Surgery"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/11999"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes abstract.","Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["Milk molecules such as mucins, antibodies, bactericidal enzymes like lysozymes and fatty acids that lyse bacteria, viral particles and bacterial peptides, offer anti-microbial activity in milk. Despite human breast milk being rich in anti-microbial substances, such as mucin, that protect against pathogens and viruses, it remains a significant route of HIV transmission from mother to child. ... The objectives of the study were to isolate, purify, identify and investigate the anti-HIV-1 activity of crude breast milk particularly the human milk fat globule material (MFGM) and its purified mucin components, in HIV positive patients (n = 20) compared with those who are not infected (n = 20). This study also tested the effect that heat (80°C, 10 min) might have on breast milk which might release the milk mucins and consequently have an inhibitory effect on HIV-1."]},{"key":"dc:title","label":"Title","values":["The role of human breast milk mucus and mucins in HIV-AIDS"]}]}],"canonical_facts":{"dc:contributor.advisor":["Mall, Anwar Suleman"],"dc:creator":["Mthembu, Yolanda"],"dc:date.accessioned":["2015-01-10T13:38:33Z"],"dc:date.available":["2015-01-10T13:38:33Z"],"dc:date.issued":["2012"],"dc:description":["Includes abstract.","Includes bibliographical references."],"dc:description.abstract":["Milk molecules such as mucins, antibodies, bactericidal enzymes like lysozymes and fatty acids that lyse bacteria, viral particles and bacterial peptides, offer anti-microbial activity in milk. Despite human breast milk being rich in anti-microbial substances, such as mucin, that protect against pathogens and viruses, it remains a significant route of HIV transmission from mother to child. ... The objectives of the study were to isolate, purify, identify and investigate the anti-HIV-1 activity of crude breast milk particularly the human milk fat globule material (MFGM) and its purified mucin components, in HIV positive patients (n = 20) compared with those who are not infected (n = 20). This study also tested the effect that heat (80°C, 10 min) might have on breast milk which might release the milk mucins and consequently have an inhibitory effect on HIV-1."],"dc:identifier.uri":["http://hdl.handle.net/11427/11999"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Surgery"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The role of human breast milk mucus and mucins in HIV-AIDS"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:18Z"}