Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection

High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the transcription factor signal transducer and activator of transcription 3 (STAT-3), has been identified as a key signalling pathway in cardioprotection, although the end effector remains unclear.

Grantor dc:publisher.institution

Division of Cardiology

Year dc:date.issued

2011

Author dc:creator

• Hacking, Damian

Advisor dc:contributor.advisor

• Lecour, Sandrine

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/11755

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/11755