{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/11621"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/11621","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy","abstract":"Distal sensory polyneuropathy (DSP) amongst human immunodeficiency virus (HIV)-infected patients is frequently a painful and disabling condition. HIV-associated DSP is either a consequence of HIV (HIV-DSP) or antiretroviral-induced toxic neuropathy (ATN). The purpose of this research was to investigate the characteristics of HIV-associated DSP over the first 24 weeks of starting cART in an African community-based cohort. Apart from studying the longitudinal association of candidate risk factors based on previous reports, we focused on two additional aspects. Firstly, the Nacetyltransferase 2 (NAT2) genotype, which determines an individual's acetylation status, influences the risk for isoniazid (INH)-associated neuropathy.","abstract_html":"Distal sensory polyneuropathy (DSP) amongst human immunodeficiency virus (HIV)-infected patients is frequently a painful and disabling condition. HIV-associated DSP is either a consequence of HIV (HIV-DSP) or antiretroviral-induced toxic neuropathy (ATN). The purpose of this research was to investigate the characteristics of HIV-associated DSP over the first 24 weeks of starting cART in an African community-based cohort. Apart from studying the longitudinal association of candidate risk factors based on previous reports, we focused on two additional aspects. Firstly, the Nacetyltransferase 2 (NAT2) genotype, which determines an individual's acetylation status, influences the risk for isoniazid (INH)-associated neuropathy.","abstract_has_math":false,"creators":["Van der Watt, Johan J"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Heckmann, Jeannine M","Dandara, Collet","Wilkinson, Robert J"],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-22T22:23:49Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/11621","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Heckmann, Jeannine M","Dandara, Collet","Wilkinson, Robert J"]},{"key":"dc:creator","label":"Author","values":["Van der Watt, Johan J"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-06T18:54:59Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-06T18:54:59Z"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/11621"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes abstract.","Thesis (Ph.D. (Medicine))--University of Cape Town, 2013."]},{"key":"dc:description.abstract","label":"Abstract","values":["Distal sensory polyneuropathy (DSP) amongst human immunodeficiency virus (HIV)-infected patients is frequently a painful and disabling condition. HIV-associated DSP is either a consequence of HIV (HIV-DSP) or antiretroviral-induced toxic neuropathy (ATN). The purpose of this research was to investigate the characteristics of HIV-associated DSP over the first 24 weeks of starting cART in an African community-based cohort. Apart from studying the longitudinal association of candidate risk factors based on previous reports, we focused on two additional aspects. Firstly, the Nacetyltransferase 2 (NAT2) genotype, which determines an individual's acetylation status, influences the risk for isoniazid (INH)-associated neuropathy."]},{"key":"dc:title","label":"Title","values":["HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy"]}]}],"canonical_facts":{"dc:contributor.advisor":["Heckmann, Jeannine M","Dandara, Collet","Wilkinson, Robert J"],"dc:creator":["Van der Watt, Johan J"],"dc:date.accessioned":["2015-01-06T18:54:59Z"],"dc:date.available":["2015-01-06T18:54:59Z"],"dc:date.issued":["2013"],"dc:description":["Includes abstract.","Thesis (Ph.D. (Medicine))--University of Cape Town, 2013."],"dc:description.abstract":["Distal sensory polyneuropathy (DSP) amongst human immunodeficiency virus (HIV)-infected patients is frequently a painful and disabling condition. HIV-associated DSP is either a consequence of HIV (HIV-DSP) or antiretroviral-induced toxic neuropathy (ATN). The purpose of this research was to investigate the characteristics of HIV-associated DSP over the first 24 weeks of starting cART in an African community-based cohort. Apart from studying the longitudinal association of candidate risk factors based on previous reports, we focused on two additional aspects. Firstly, the Nacetyltransferase 2 (NAT2) genotype, which determines an individual's acetylation status, influences the risk for isoniazid (INH)-associated neuropathy."],"dc:identifier.uri":["http://hdl.handle.net/11427/11621"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:49Z"}