{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/11589"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/11589","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome","abstract":"While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a significant subset of these patients. TB-IRIS is an inflammatory complication of the combined treatments for HIV-1 and tuberculosis, which is being reported increasingly, particularly in areas endemic to both diseases. This work aimed to characterise the immunopathogenesis of paradoxical HIV-Tuberculosis associated immune reconstitution inflammatory syndrome.","abstract_html":"While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a significant subset of these patients. TB-IRIS is an inflammatory complication of the combined treatments for HIV-1 and tuberculosis, which is being reported increasingly, particularly in areas endemic to both diseases. This work aimed to characterise the immunopathogenesis of paradoxical HIV-Tuberculosis associated immune reconstitution inflammatory syndrome.","abstract_has_math":false,"creators":["Tadokera, Rabecca"],"institution":"Institute of Infectious Disease and Molecular Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Wilkinson, Robert J","Wilkinson, Katalin"],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-22T22:23:00Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/11589","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Wilkinson, Robert J","Wilkinson, Katalin"]},{"key":"dc:creator","label":"Author","values":["Tadokera, Rabecca"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-06T18:45:03Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-06T18:45:03Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Institute of Infectious Disease and Molecular Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/11589"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a significant subset of these patients. TB-IRIS is an inflammatory complication of the combined treatments for HIV-1 and tuberculosis, which is being reported increasingly, particularly in areas endemic to both diseases. This work aimed to characterise the immunopathogenesis of paradoxical HIV-Tuberculosis associated immune reconstitution inflammatory syndrome."]},{"key":"dc:title","label":"Title","values":["Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome"]}]}],"canonical_facts":{"dc:contributor.advisor":["Wilkinson, Robert J","Wilkinson, Katalin"],"dc:creator":["Tadokera, Rabecca"],"dc:date.accessioned":["2015-01-06T18:45:03Z"],"dc:date.available":["2015-01-06T18:45:03Z"],"dc:date.issued":["2011"],"dc:description.abstract":["While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a significant subset of these patients. TB-IRIS is an inflammatory complication of the combined treatments for HIV-1 and tuberculosis, which is being reported increasingly, particularly in areas endemic to both diseases. This work aimed to characterise the immunopathogenesis of paradoxical HIV-Tuberculosis associated immune reconstitution inflammatory syndrome."],"dc:identifier.uri":["http://hdl.handle.net/11427/11589"],"dc:language.iso":["eng"],"dc:publisher.department":["Institute of Infectious Disease and Molecular Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:00Z"}