{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/11363"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/11363","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape","abstract":"HIV-associated neurocognitive disorders (HAND) remain prevalent in the era of highly active anti-retroviral therapy (HAART). The aim of the study was to investigate whether HAND are as prevalent in South Africa as in other regions, and whether individuals with HAND in South Africa will respond to HAART. The literature was reviewed to elucidate potential mechanisms of the development of HIV-associated dementia (HAD), the most severe form of HAND, and to establish the effect that HAART has exerted on HAND across diverse studies. A prospective clinical cohort study was initiated in Cape Town, comprising 170 participants. The reviewed literature suggests that HAD is likely mediated by a range of HIV-related factors (including possible difference in HIV sub-type) and host-related factors.","abstract_html":"HIV-associated neurocognitive disorders (HAND) remain prevalent in the era of highly active anti-retroviral therapy (HAART). The aim of the study was to investigate whether HAND are as prevalent in South Africa as in other regions, and whether individuals with HAND in South Africa will respond to HAART. The literature was reviewed to elucidate potential mechanisms of the development of HIV-associated dementia (HAD), the most severe form of HAND, and to establish the effect that HAART has exerted on HAND across diverse studies. A prospective clinical cohort study was initiated in Cape Town, comprising 170 participants. The reviewed literature suggests that HAD is likely mediated by a range of HIV-related factors (including possible difference in HIV sub-type) and host-related factors.","abstract_has_math":false,"creators":["Joska, John Anton"],"institution":"Department of Psychiatry and Mental Health","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Flisher, Alan J","Stein, Dan J"],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-22T22:23:30Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/11363","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Flisher, Alan J","Stein, Dan J"]},{"key":"dc:creator","label":"Author","values":["Joska, John Anton"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-05T06:59:42Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-05T06:59:42Z"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Psychiatry and Mental Health"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/11363"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes abstract.","Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["HIV-associated neurocognitive disorders (HAND) remain prevalent in the era of highly active anti-retroviral therapy (HAART). The aim of the study was to investigate whether HAND are as prevalent in South Africa as in other regions, and whether individuals with HAND in South Africa will respond to HAART. The literature was reviewed to elucidate potential mechanisms of the development of HIV-associated dementia (HAD), the most severe form of HAND, and to establish the effect that HAART has exerted on HAND across diverse studies. A prospective clinical cohort study was initiated in Cape Town, comprising 170 participants. The reviewed literature suggests that HAD is likely mediated by a range of HIV-related factors (including possible difference in HIV sub-type) and host-related factors."]},{"key":"dc:title","label":"Title","values":["Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape"]}]}],"canonical_facts":{"dc:contributor.advisor":["Flisher, Alan J","Stein, Dan J"],"dc:creator":["Joska, John Anton"],"dc:date.accessioned":["2015-01-05T06:59:42Z"],"dc:date.available":["2015-01-05T06:59:42Z"],"dc:date.issued":["2010"],"dc:description":["Includes abstract.","Includes bibliographical references."],"dc:description.abstract":["HIV-associated neurocognitive disorders (HAND) remain prevalent in the era of highly active anti-retroviral therapy (HAART). The aim of the study was to investigate whether HAND are as prevalent in South Africa as in other regions, and whether individuals with HAND in South Africa will respond to HAART. The literature was reviewed to elucidate potential mechanisms of the development of HIV-associated dementia (HAD), the most severe form of HAND, and to establish the effect that HAART has exerted on HAND across diverse studies. A prospective clinical cohort study was initiated in Cape Town, comprising 170 participants. The reviewed literature suggests that HAD is likely mediated by a range of HIV-related factors (including possible difference in HIV sub-type) and host-related factors."],"dc:identifier.uri":["http://hdl.handle.net/11427/11363"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Psychiatry and Mental Health"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:30Z"}