Social trauma and the mu-opioid system in depression

The overarching thesis under investigation is that the endogenous opioid system plays a key role in depression subsequent to traumatic childhood social experiences. This is suggested by the fact that animal work indicates that mu-opioids robustly mediate separation-distress, and that early social stressors lead to long term dysregulation in key related circuitries and neuroanatomical structures.

Grantor dc:publisher.institution

Department of Psychology

Year dc:date.issued

2011

Author dc:creator

• Malcolm-Smith, Susan

Advisors dc:contributor.advisor

• Thomas, Kevin
• Solms, Mark

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/11123

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/11123