{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/11086"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/11086","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis","abstract":"Proteins mediate bio-chemical processes in cellular organisms by functioning as structural components, signaling molecules, enzymes, transcription factors and receptors, through complex interactions that they make with one another. The study of protein-protein interactions (PPI) within an organism is thus a vital step towards understanding the cellular life process of an organism. PPIs have been studied by specially designed experiments to identify pairs of proteins that are suspected to interact. Experimental approaches are quite expensive, yet still there are cases of wrongly identified protein-protein interactions. In this study, we predict PPIs computationally by exploiting known properties of proteins and PPIs and the requirement that proteins be present in the same cell compartment at the same time in order to interact (subcellular localization and gene expression).","abstract_html":"Proteins mediate bio-chemical processes in cellular organisms by functioning as structural components, signaling molecules, enzymes, transcription factors and receptors, through complex interactions that they make with one another. The study of protein-protein interactions (PPI) within an organism is thus a vital step towards understanding the cellular life process of an organism. PPIs have been studied by specially designed experiments to identify pairs of proteins that are suspected to interact. Experimental approaches are quite expensive, yet still there are cases of wrongly identified protein-protein interactions. In this study, we predict PPIs computationally by exploiting known properties of proteins and PPIs and the requirement that proteins be present in the same cell compartment at the same time in order to interact (subcellular localization and gene expression).","abstract_has_math":false,"creators":["Opap, Kenneth Babu"],"institution":"Department of Molecular and Cell Biology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Mulder, Nicola"],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-22T22:22:51Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/11086","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Mulder, Nicola"]},{"key":"dc:creator","label":"Author","values":["Opap, Kenneth Babu"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-03T05:29:18Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-03T05:29:18Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Molecular and Cell Biology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/11086"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references (leaves 96-103)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Proteins mediate bio-chemical processes in cellular organisms by functioning as structural components, signaling molecules, enzymes, transcription factors and receptors, through complex interactions that they make with one another. The study of protein-protein interactions (PPI) within an organism is thus a vital step towards understanding the cellular life process of an organism. PPIs have been studied by specially designed experiments to identify pairs of proteins that are suspected to interact. Experimental approaches are quite expensive, yet still there are cases of wrongly identified protein-protein interactions. In this study, we predict PPIs computationally by exploiting known properties of proteins and PPIs and the requirement that proteins be present in the same cell compartment at the same time in order to interact (subcellular localization and gene expression)."]},{"key":"dc:title","label":"Title","values":["An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis"]}]}],"canonical_facts":{"dc:contributor.advisor":["Mulder, Nicola"],"dc:creator":["Opap, Kenneth Babu"],"dc:date.accessioned":["2015-01-03T05:29:18Z"],"dc:date.available":["2015-01-03T05:29:18Z"],"dc:date.issued":["2011"],"dc:description":["Includes bibliographical references (leaves 96-103)."],"dc:description.abstract":["Proteins mediate bio-chemical processes in cellular organisms by functioning as structural components, signaling molecules, enzymes, transcription factors and receptors, through complex interactions that they make with one another. The study of protein-protein interactions (PPI) within an organism is thus a vital step towards understanding the cellular life process of an organism. PPIs have been studied by specially designed experiments to identify pairs of proteins that are suspected to interact. Experimental approaches are quite expensive, yet still there are cases of wrongly identified protein-protein interactions. In this study, we predict PPIs computationally by exploiting known properties of proteins and PPIs and the requirement that proteins be present in the same cell compartment at the same time in order to interact (subcellular localization and gene expression)."],"dc:identifier.uri":["http://hdl.handle.net/11427/11086"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Molecular and Cell Biology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["An integrative approach to studying protein-protein interactions within the genome of Mycobacterium tuberculosis"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:22:51Z"}