{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/11069"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/11069","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease","abstract":"Early developmental stress has been shown to produce numerous deleterious effects, e.g. the later development of affective disorders, and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies have shown that maternally separated rats exhibit increased anxiety- and depression-like behaviour in adulthood, although other evidence shows hyperactivity and impulsivity in such cases. Given that stress has these behavioural effects, it is of interest to determine whether early developmental stress might enhance the toxicity of a later unrelated neural insult. The 6-hydroxydopamine (6-OHDA) model of Parkinson's disease involves the selective unilateral lesion of nigrostriatal dopamine neurons. In this group of studies it was hypothesized that maternal separation might enhance the toxic effects of 6-OHDA.","abstract_html":"Early developmental stress has been shown to produce numerous deleterious effects, e.g. the later development of affective disorders, and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies have shown that maternally separated rats exhibit increased anxiety- and depression-like behaviour in adulthood, although other evidence shows hyperactivity and impulsivity in such cases. Given that stress has these behavioural effects, it is of interest to determine whether early developmental stress might enhance the toxicity of a later unrelated neural insult. The 6-hydroxydopamine (6-OHDA) model of Parkinson's disease involves the selective unilateral lesion of nigrostriatal dopamine neurons. In this group of studies it was hypothesized that maternal separation might enhance the toxic effects of 6-OHDA.","abstract_has_math":false,"creators":["Warton, Fleur L"],"institution":"Division of Neurosurgery","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Russell, Vivienne A"],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-22T22:23:05Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/11069","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Russell, Vivienne A"]},{"key":"dc:creator","label":"Author","values":["Warton, Fleur L"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-03T05:23:55Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-03T05:23:55Z"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Neurosurgery"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/11069"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references (p. 224-253)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Early developmental stress has been shown to produce numerous deleterious effects, e.g. the later development of affective disorders, and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies have shown that maternally separated rats exhibit increased anxiety- and depression-like behaviour in adulthood, although other evidence shows hyperactivity and impulsivity in such cases. Given that stress has these behavioural effects, it is of interest to determine whether early developmental stress might enhance the toxicity of a later unrelated neural insult. The 6-hydroxydopamine (6-OHDA) model of Parkinson's disease involves the selective unilateral lesion of nigrostriatal dopamine neurons. In this group of studies it was hypothesized that maternal separation might enhance the toxic effects of 6-OHDA."]},{"key":"dc:title","label":"Title","values":["The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease"]}]}],"canonical_facts":{"dc:contributor.advisor":["Russell, Vivienne A"],"dc:creator":["Warton, Fleur L"],"dc:date.accessioned":["2015-01-03T05:23:55Z"],"dc:date.available":["2015-01-03T05:23:55Z"],"dc:date.issued":["2010"],"dc:description":["Includes bibliographical references (p. 224-253)."],"dc:description.abstract":["Early developmental stress has been shown to produce numerous deleterious effects, e.g. the later development of affective disorders, and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies have shown that maternally separated rats exhibit increased anxiety- and depression-like behaviour in adulthood, although other evidence shows hyperactivity and impulsivity in such cases. Given that stress has these behavioural effects, it is of interest to determine whether early developmental stress might enhance the toxicity of a later unrelated neural insult. The 6-hydroxydopamine (6-OHDA) model of Parkinson's disease involves the selective unilateral lesion of nigrostriatal dopamine neurons. In this group of studies it was hypothesized that maternal separation might enhance the toxic effects of 6-OHDA."],"dc:identifier.uri":["http://hdl.handle.net/11427/11069"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Neurosurgery"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:05Z"}