{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/11067"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/11067","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract","abstract":"T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the female genital tract and blood in uninfected compared to HIV-infected women; and (2) to investigate the role of inflammatory/regulatory cytokines and bacterial burden in modulating Th17 cell frequencies in genital secretions and plasma.","abstract_html":"T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the female genital tract and blood in uninfected compared to HIV-infected women; and (2) to investigate the role of inflammatory/regulatory cytokines and bacterial burden in modulating Th17 cell frequencies in genital secretions and plasma.","abstract_has_math":false,"creators":["Salkinder, Amy Leia"],"institution":"Division of Medical Microbiology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Passmore, Jo-Ann"],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-22T22:23:33Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/11067","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Passmore, Jo-Ann"]},{"key":"dc:creator","label":"Author","values":["Salkinder, Amy Leia"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-03T04:59:31Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-03T04:59:31Z"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Medical Microbiology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/11067"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references (leaves 85-103)."]},{"key":"dc:description.abstract","label":"Abstract","values":["T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the female genital tract and blood in uninfected compared to HIV-infected women; and (2) to investigate the role of inflammatory/regulatory cytokines and bacterial burden in modulating Th17 cell frequencies in genital secretions and plasma."]},{"key":"dc:title","label":"Title","values":["Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract"]}]}],"canonical_facts":{"dc:contributor.advisor":["Passmore, Jo-Ann"],"dc:creator":["Salkinder, Amy Leia"],"dc:date.accessioned":["2015-01-03T04:59:31Z"],"dc:date.available":["2015-01-03T04:59:31Z"],"dc:date.issued":["2010"],"dc:description":["Includes bibliographical references (leaves 85-103)."],"dc:description.abstract":["T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the female genital tract and blood in uninfected compared to HIV-infected women; and (2) to investigate the role of inflammatory/regulatory cytokines and bacterial burden in modulating Th17 cell frequencies in genital secretions and plasma."],"dc:identifier.uri":["http://hdl.handle.net/11427/11067"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Medical Microbiology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:33Z"}