Prevalence and incidence of renal dysfunction in patients initiating Antiretroviral Therapy at a Primary Health Care Centre in Gugulethu, Cape Town : a cohort study

Tenofovir disoproxil fumarate (TDF) is used worldwide for the treatment of HIV-1 infection. Tenofovir has been found to be associated with declines in renal function and chronic kidney disease in HIV-infected patients. There are limited data on how soon after antiretroviral therapy (ART) initiation any loss of renal function can be detected. We studied a cohort of HIV-infected adults initiating TDF-containing ART regimens at the Hannan Crusaid Antiretroviral Treatment Centre in Gugulethu. The centre provides ART to the residents of the Gugulethu and Nyanga districts situated on the outskirts of Cape Town. We described the prevalence and incidence of renal dysfunction in this cohort, the patterns of change in their renal function in the first 12 months on therapy and factors associated with renal dysfunction. We also examined the diagnostic value of early serum creatinine tests in identifying incident renal dysfunction after 12 months.

Grantor dc:publisher.institution

Department of Public Health and Family Medicine

Year dc:date.issued

2013

Author dc:creator

• Kamkuemah, Monika

Advisors dc:contributor.advisor

• Myer, Landon
• Little, Francesca

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/11002

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/11002