Determinants of innate immune responses to mycobacteria

Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers. The type and magnitude of innate responses to mycobacteria may determine the subsequent adaptive responses generated. Our aims were to determine maturational changes in innate immune responses to mycobacteria over the first 9 months of life, and to assess effects of genetic variations in toll-like receptors on host responses to mycobacteria. This knowledge is important for designing rational strategies for vaccination against tuberculosis.

Grantor dc:publisher.institution

Department of Paediatrics and Child Health

Year dc:date.issued

2012

Author dc:creator

• Shey, Muki Shehu

Advisors dc:contributor.advisor

• Hanekom, Willem A
• Scriba, Thomas J

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/10986

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/10986