An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation

The glucocorticoid receptor (GR) is a ligand-activated transcription factor which, due to its central role in anti-inflammatory responses, is a target of many therapeutically prescribed drugs. The GR undergoes multiple post-translational modifications, including phosphorylation and acetylation; however the role of GR acetylation in transactivation is unclear.

Grantor dc:publisher.institution

Department of Molecular and Cell Biology

Year dc:date.issued

2010

Author dc:creator

• Hadley, Katie Emma

Advisor dc:contributor.advisor

• Hapgood, Janet

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/10607

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/10607